The mathematics are quite clear on this subject. Blackjack with optimal basic strategy yields approximately a 0.36-0.44% house edge in Atlantic City variants. However, achieving long-term profitability requires advanced techniques such as card counting, which involves assigning values (+1 for low cards 2-6, 0 for 7-9, -1 for high cards 10-A) and calculating true count by dividing running count by remaining decks. The theoretical advantage exists, but practical implementation faces significant obstacles including casino countermeasures and bankroll requirements.